Milestone 1

  • Due: M12

First generation of MOF catalyst for oxidative alkenylation with improved catalytic performance  available.

By testing the reactions of interest at lab-scale, the activity and leaching-free nature will be assessed, and compared to the targets (TON ≥ 200 and metal leaching < 20 ppm).

Milestone 10

  • Due: M03

Project Website functional.

Functional website goes on-line including public and partners sections facilitating communication and dissemination.

Milestone 2

  • Due: M12

First generation of MOF or hybrid silica catalyst for indole arylation with improved catalytic performance available.

By testing the reactions of interest at lab-scale, the activity and leaching-free nature will be assessed, and compared to the targets (TON ≥ 100 and metal leaching < 20 ppm).

Milestone 3

  • Due: M30

Second generation of MOF catalyst for oxidative alkenylation with improved catalytic activity available.

By catalytic testing at lab scale, and evaluating the results, we can measure the TON value (= activity), and compare it to the target (TON ≥ 1000 and metal leaching < 20 ppm).

Milestone 4

  • Due: M30

Second generation of MOF or hybrid silica catalyst for indole arylation with improved catalytic activity available

By catalytic testing at lab scale, and evaluating the results, we can measure the TON value (= activity), and compare it to the target (TON ≥ 500 and metal leaching < 20 ppm).

Milestone 5

  • Due: M36

Catalyst with enhanced positional selectivity available.

The positional selectivity will be measured, and compared to the target value (90 % for the Rilpivirine precursor).

Milestone 6

  • Due: M33

Validation of up-scaling and shaping of MOF-type catalyst for alkenylation.

90 % of the activity with respect to powder is maintained after upscaling and shaping, and environmentally acceptable preparation conditions are used.

Milestone 7

  • Due: M33

Validation of up-scaling and shaping of MOF or hybrid silica catalyst for indole arylation.

90 % of the activity with respect to powder is maintained after upscaling and shaping, and environmentally acceptable preparation conditions are used.

Milestone 8

  • Due: M39

Reaction for Rilpivirine precursor demonstrated at 50 l scale with hybrid catalyst.

Analysis of the reaction outcome (yield of alkenylated product; absence of leaching) confirms that shaped catalyst displays robust performance in industrial setting.

Milestone 9

  • Due: M40

Validation  of the techno-economic relevance of the process.

The global cost and performance of catalyst production will be assessed (WP6) and compared with catalysts currently marketed by the technology providers and end-users. The targeted final cost of the catalysts must be comparable to the price of existing ones, combined with improved performance.