H-CCAT brings together a a consortium of partners from academia and private industry with the aim of developing new hybrid catalyst materials for C-H bond activation.
Axel’One is an independent association (French law 1901) having eight founding members : CNRS, CPE Lyon , Lyon ENS , IFP Energies nouvelles, INSA, Solvay, Suez Environnement and Lyon 1 university.
Axel’One is a collaborative innovation platform in the chemistry and environment Sector dedicated to clean processes and innovative materials.
Our main missions consist of providing shared facilities, tools and services (kilo labs, chemistry laboratories, scale up pilots) to collaborative research and development projects. These services are open to all stakeholders including SMEs and enable users to carry out R&D projects, tests, scale-up towards industrial process, pre-series production.
The expected benefits are numerous:
promote SME access to infrastructure usually reserved for large companies
increase the number of innovative projects and promote joint projects
facilitate the industrialization of R&D results through existing appropriate tools
allow the emergence of new advanced tools
In 2015, Axel’One has hosted 10 SMEs, provided its services to 11 different R&D program representing 150 people on 8 500 m2. Axel’One turnover for 2015 was 3.3 M€.
The Centre National de la Recherche Scientifique (French National Center for Scientific Research) is a public organisation for scientific and technological research and is under the authority of the French Ministry for Research. The CNRS is also the largest fundamental research organisation in Europe. Measured by the amount of human and material resources it commits to scientific research or by the great range of disciplines in which its scientists carry on their work, the CNRS is clearly the hub of research activity in France. It is also an important breeding ground for scientific and technological innovation.
Research Institute for Catalysis and Environment of Lyon
IRCELYON (Research Institute for Catalysis and Environment of Lyon) was founded in 2007 and is the largest national department devoted to the development of catalytic and environmental remediation processes. The "Engineering from material to process" (ENG) team (~10 permanent staffs and 20-25 students) at the center of this project has already gained a large experience of materials and process development in the frame of European projects
The development of MOF as catalysts was initiated in 2008 at IRCELYON for materials in their as-synthesized form. In the frame of the French ANR project ACACIA and FP7 OCMOL, post-synthetic modifications methodologies were developed to finely tune the catalytic properties of MOF solids towards enhanced catalytic activity. Our group is expert and has proprietary solutions for the functionalisation of MOF by post-synthetic modifications (7 patents) which will be applied in H-CCAT. In the last few years, our group has provided numerous studies on MOF-based catalysts design paying attention to both effect of structural defects and post-synthetic anchoring of active molecular species.
This experience and expertise in MOF synthesis, functionalization, characterization and catalysis ideally matches the work proposed within the H-CCAT project. In addition, the background in Chemical Engineering and pilot testing will allow designing suitable materials from start for real process conditions, thus ensuring key issues such as scale-up, shaping and conditioning among others. Finally, the consortium will benefit of numbers of testing facilities for solids characterization.
Laboratory of Chemistry, Catalysis, Polymers and Processes
C2P2 (Laboratory of Chemistry, Catalysis, Polymers and Processes) was founded in 2007 as a result of the fusion of the Laboratory for the Chemistry and Processes of Polymerisation) and the Laboratory for Surface Organometallic Chemistry. The research topics are logically at the interface of organometallic chemistry, surface science, catalysis and nanomaterials for the SOMC team, and cover all chemistries of polymerization for the LCPP team (catalytic polymerization of olefins, polycondensation, different forms of radical polymerizations).
The major focus of the research at the C2P2 is on the use of fundamental chemistry, catalysis, and chemical engineering to enhance our ability to produce organic, inorganic and composite materials, and to propose the processes used for this purpose. More specifically, the LCOMS team, partner of H-CCAT, aims at developing innovative heterogeneous well-defined and single site catalysts. These catalysts are developped via the controlled grafting of organometallic complexes onto inorganic or hybrid supports (of which organo-silicas or MOF), the latter supports being prepared by a « chimie douce » approach (sol-gel process, solvothermal syntheses…) with a molecular control over the localization and the distribution of the active sites within the solid matrix.
This experience and expertise in the preparation/characterization of hybrid materials synthesis and catalysts testings match the work proposed within the H-CCAT project. The consortium will therefore benefit from a large number of facilities of which equipments for the synthesis of air sensitive compounds, solid state RMN setups (300 and 500 MHz), a high resolution transmission electron microscope (JEOL 2100), gas adsorption apparatus (in flow and static conditions), transmission and diffusion reflectance FT-IR spectrometers and UV-Vis. Spectrometers.
Institute Charles Gerhardt in Montpellier
ICGM (Institute Charles Gerhardt in Montpellier) is one of the largest chemistry institutes of France. ICGM, which is funded by the National Center for Scientific Research (CNRS) and the French Ministry for Education and Research, is composed of 11 research groups comprising about 230 permanent researchers. The ICGM researchers involved in the HCCAT project belong to the CMOS group, which gathers chemists and physical chemists from various fields, including inorganic and macromolecular chemistry, and Si and P molecular chemistry. The objective of the CMOS group is to develop innovating routes for the synthesis, the structuration and the control of surface/interface properties of inorganic, organic, and hybrid materials. The main targeted applications are in the fields of heterogeneous catalysis and energy storage.
Fraunhofer is Europe’s largest application-oriented research organization. The Fraunhofer-Gesellschaft undertakes applied research of direct for use by private and public enterprise and of benefit to society working on projects with applied research and demonstration activities for industrial applications, amongst others. The Fraunhofer-Institute for Ceramic Technologies and Systems IKTS, situated in Dresden and Hermsdorf, covers the complete field of advanced ceramics, from basic research to applications. The IKTS undertakes work on the development and application of modern high performance materials, on the development of industrial powder technologies in order to produce these materials and on the manufacturing of prototypical components. The R&D process follows all the stages of product development, from production of the materials to the development and optimization of the structure/property relationships through to the application/system integration stage. In terms of shaping technologies for nano-porous materials like MOFs or zeolites, IKTS has numerous equipment and substantial large know-how for production of shaped bodies for various applications. Furthermore, IKTS have substantial devices and know-how for characterization of nano-porous materials and components.
The University of Goettingen is an internationally renowned university placing emphasis on research and research-based teaching. The University is distinguished by the outstanding quality in its priority research areas, by its remarkable diversity of disciplines, especially in the humanities, and by a strong and deeply anchored interdisciplinarity in the natural and life sciences. Research excellence of international standard is currently recognized in
- the life sciences – Neurosciences, Molecular Biology, Biodiversity and Ecology,
- the natural sciences – Chemistry, Physics of Condensed Matter and Optics, Geobiology, and Pure Mathematics, and
- the humanities – German Language and Literature Studies, Oriental and Ancient World Studies, and Theology.
Janssen Pharmaceutica NV was founded by Dr. Paul Janssen in 1953 with only one thing in mind: saving people’s lives thanks to the development of better medicines. In 1961, the company affiliated with the Johnson & Johnson Group, global market leader in healthcare products, with its headquarters in New Brunswick, USA. The group has more than 265 operational companies in 60 countries today and more than 128,000 employees worldwide. Belgium is the largest Johnson & Johnson site outside the United States and therefore occupies a major position in the American concern.
Since 2011, all Johnson & Johnson pharmaceutical activities have continued under one name: Janssen Pharmaceutical Companies of Johnson & Johnson. Today, Janssen is one of the most innovative pharmaceutical companies in the world, as recognized by IDEA Pharma: Johnson & Johnson tops IDEA Pharma’s Productive Innovation Index for the fourth consecutive year. Janssen employs more than 40,000 employees, 4,600 of which in Belgium. The company invests around $4.5 billion in research & development annually and is a top 10 company in global pharmaceutical sales.
Janssen R&D shares an overarching mission: to discover and develop innovative medicines and solutions that transform individuals’ lives and solve the most important unmet medical needs of our time. As Janssen R&D, we work together to harness our combined knowledge and resources, leverage the power and promise of outstanding science and enhance the length and quality of life for people throughout the world.
The ‘Pharmaceutical Development & Manufacturing Sciences’ department has the capabilities to produce active ingredients, develop drug product solutions and to manufacture clinical trial material to support studies at the different phases of development. In addition it has a commercial manufacturing infrastructure as well.
Johnson Matthey is a UK based speciality chemicals company focused on its core skills in catalysis, precious metals, fine chemicals and process technology. The company employs around 13,000 people worldwide located in over 30 countries; around 10% of those work in an R&D function. Johnson Matthey's principal activities are the manufacture of autocatalysts, heavy duty diesel catalysts and pollution control systems, catalysts and components for fuel cells, catalysts and technologies for chemical processes, fine chemicals, chemical catalysts and active pharmaceutical ingredients and the marketing, refining, and fabrication of precious metals. More than half of JM’s products have a direct environmental benefit, a figure that is set to increase as a key part of the company’s growth strategy is to focus on emerging environmental opportunities. Johnson Matthey’s Fine Chemicals is one of five divisions within JM group, and a key part of the company's strategy for future growth. The division is a global supplier of heterogeneous, homogeneous, chiral and biocatalytic technologies for the pharmaceutical, fine chemical and agrochemical industries industries. JM’s participation in this project will be through the Technology Centre (JMTC) based at Sonning Common in the UK. This central facility acts as a focal point for the development of new technologies into emerging market applications.
KU Leuven is currently by far the largest university in Belgium in terms of research funding and expenditure (EUR 426.5 million in 2014), and is a charter member of LERU. KU Leuven conducts fundamental and applied research in all academic disciplines with a clear international orientation. Leuven participates in over 540 highly competitive European research projects (FP7, 2007-2013), ranking sixth in the league of HES institutions participating in FP7. In Horizon 2020, KU Leuven currently has been approved 125 projects.
Centre of Surface Chemistry and Catalysis (COK)
Within KU Leuven, the COK constitutes a large interdisciplinary team involved in teaching and research in the chemistry of the solid-gas, solid-liquid, and solid-solid interphases. The COK has been recognized in several ways to be a centre of excellence for research and teaching of interphase chemistry and catalysis at KU Leuven and to promote interphase chemistry and catalysis at European and international levels Over the past years, the COK has grown substantially and currently counts more than 120 people.
Sustainable Metals Processing and Recyclinga
The Sustainable Metals Processing and Recycling and more specifically the group of Sustainability Assessments of Material Life Cycles specializes in life cycle assessment of materials processes. Besides from assessing the sustainability a mission is to develop methodologies to improve the life cycle impact of materials through closing material loops. Some fields of application are high temperature residues, landfill mining and CFRP composite materials and bio-based resins. The highly interdisciplinary group takes place in a wide variety of initiatives.
ProfMof is founded in order to offer high quality grade MOFs (Metallic Organic Frameworks) to the cooling industry, the automotive industry and the oil & gas industry. Our MOF, designated UiO-66 and CAU-10 is developed at the University of Oslo (UiO) and the University of Kiel (UiK) with the purpose of addressing some of the main global challenges such as safer and more efficient storage of natural gas, more energy efficient cooling and the separation of gases. We aim to create a production process that is cost efficient on a large scale.
The research groups of Lillerud, Olsbye and Stock that are behind ProfMOF have a strong history in the synthesis of MOFs in general and their groups have discovered the materials that are in the main focus of the H-CCAT project: UiO-66 [patents: US 8653292 and EP EP2291384] and UiO-67. The research aiming at developing methods for green and low cost synthesis, especially water-based routes, are ongoing goals and are financed by the Norwegian FORNY project (12.3 mill NOK) and the EU-Horizon 2020 project ProDIA where the water based synthesis of Zr-based MOFs is supported with 5.3 mill NOK.
Taking profit of this knowledge ProfMOF has established syntheses of MOFs at the 1, 3 and 20 L scale for which batch reactors are available that allow the synthesis of up to 1 kg of CAU-10 and UiO-66-COOH, or 900 g of UiO-66-NH2 at a time. ProfMOF has contracts with companies equipped with large scale batch reactors that can be rented and allow for the synthesis of the MOFs at the 500 L scale. At the same time flow reactors have been set up, that allow for the continuous synthesis of the aforementioned MOFs in the range of 1kg per day, running the reactor for 6 h.
SiKÉMIA is a French company specialized in the field of materials surface functionalization.
SiKÉMIA develops and produces innovative couplings agents (gram to hundred kilos) in Silicon, Phosphorus and Sulphur Chemistry with a wide range of applications including AntiAdhesion, CrossLinking, BioRecognition, Dispersibilty, Adhesion Promotion, etc.
Via custom services, SiKÉMIA is also able to design and synthesize original ligands and realize surface modification studies.
Green SOC has been contributing to the development of novel synthetic processes efficient from both chemical and environmental point of views. The attention has been mainly directed towards the definition of waste-minimized and sustainable chemical processes that could be realized using safer recoverable reaction media and evaluated by appropriate green metrics. In order to realize large scale processes operating in automated continuous-flow conditions, solid supports (organic or inorganic) have designed to be used in flow and deal with the related swelling processes. Green SOC is recently focusing on the definition of efficient protocols for cross-coupling and C‑H activation processes in the preparation of target materials focusing on the use of heterogeneous catalytic systems and on the replacement of classic dipolar aprotic media.